abstract：OBJECTIVES:To analyze the relationship between office and ambulatory heart rate, and its variability, and arterial stiffness in patients with primary arterial hypertension. METHODS:A cross-sectional study was conducted in a primary care setting, with the inclusion of 356 hypertensive patients aged 30-80 years. Office ...

journal_title：Atherosclerosis

authors： García-Ortiz L,García-García A,Ramos-Delgado E,Patino-Alonso MC,Recio-Rodríguez JI,Rodríguez-Sánchez E,Gómez-Marcos MA

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Postprandial hyperlipemia has been shown to impair endothelial function and contribute to the development of atherosclerosis. We investigated the association between postprandial lipid profiles and endothelial function, and we examined the effects of ezetimibe on postprandial hyperlipemia and lipemia-induced ...

journal_title：Atherosclerosis

authors： Yunoki K,Nakamura K,Miyoshi T,Enko K,Kohno K,Morita H,Kusano KF,Ito H

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Racial/ethnic differences in common carotid artery intima-media thickness (CIMT) and in risk factors associated with CIMT have been predominantly observed in middle-aged and older individuals. We aimed to characterize racial/ethnic differences CIMT and other cardiovascular risk factors in a healthy, young-adu...

journal_title：Atherosclerosis

authors： Breton CV,Wang X,Mack WJ,Berhane K,Lopez M,Islam TS,Feng M,Hodis HN,Künzli N,Avol E

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The scavenger receptor SR-PSOX/CXCL16, which is identical to the chemokine CXCL16, is thought to be involved in atherogenesis. However, the presence and function of SR-PSOX/CXCL16 in the endothelium of atherosclerotic arteries has not been substantiated. METHODS AND RESULTS:In rabbit aorta immunocytochemistr...

journal_title：Atherosclerosis

authors： Hofnagel O,Engel T,Severs NJ,Robenek H,Buers I

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Although the combination of statins with n-3 fatty acids seems to be beneficial under the lipid profile aspect, there is little information about the interaction of these two compounds on oxidative stress. OBJECTIVE:Evaluate the interaction between statins and n-3 fatty acids on oxidative stress in women,...

journal_title：Atherosclerosis

authors： Carrepeiro MM,Rogero MM,Bertolami MC,Botelho PB,Castro N,Castro IA

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To explore the cardiovascular disease (CVD) risk in prehypertensive subjects and evaluate whether high blood pressure (BP) is associated with insulin resistance (IR) and β-cell dysfunction. METHODS:A total of 2949 people aged 20-94 years old were selected in Fujian province of China. We assessed CVD risk usi...

journal_title：Atherosclerosis

authors： Chen G,Lai X,Jiang Q,Chen F,Chen N,Huang H,Liang J,Li L,Wen J,Lin L,Yao J

更新日期：2011-07-01 00:00:00

abstract：:Investigations to date have demonstrated that the underlying etiology, causes and burden of stroke may be different for women and men. However, data regarding sex differences among young cerebral ischemic stroke patients remains scarce. We conducted this study in 669 young Chinese adults with acute ischemic stroke as ...

journal_title：Atherosclerosis

authors： Zhang B,Pu S,Zhang W,Yang N,Shen G,Yin J,Yi Y,Gao Q,Gao C

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:High homocysteine level is a risk factor for atherosclerosis and has been associated with lacunar infarcts (LIs), white matter lesions (WML) and cognitive dysfunction. It is unclear whether homocysteine is associated with cerebral small vessel disease (cSVD) on top of pre-existent atherosclerosis. We evaluate...

journal_title：Atherosclerosis

authors： Kloppenborg RP,Nederkoorn PJ,van der Graaf Y,Geerlings MI

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Familial hypercholesterolemia (FH) is a heterogeneous autosomal dominant disease with a prevalence of 1 in 500. To date, over 1200 unique pathogenic mutations have been identified in at least 3 genes. The large allelic and genetic heterogeneity of FH requires high-throughput, rapid, and affordable mutation d...

journal_title：Atherosclerosis

authors： Chiou KR,Charng MJ,Chang HM

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To investigate the association between a low ankle-brachial index (ABI) and several grades of cognitive disorders: cognitive impairment, dementia and Alzheimer's disease (AD), in the general population. METHODS:We performed a systematic review of the literature, including all prospective, longitudinal or cro...

journal_title：Atherosclerosis

authors： Guerchet M,Aboyans V,Nubukpo P,Lacroix P,Clément JP,Preux PM

更新日期：2011-06-01 00:00:00

abstract：:Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as a new pharmacological target for hypercholesterolemia, and different PCSK9 inhibitors are now evaluated in clinical trials. Here, we propose a...

journal_title：Atherosclerosis

authors： Cariou B,Le May C,Costet P

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS:Patients that underwent femoral or carot...

journal_title：Atherosclerosis

authors： Herisson F,Heymann MF,Chétiveaux M,Charrier C,Battaglia S,Pilet P,Rouillon T,Krempf M,Lemarchand P,Heymann D,Gouëffic Y

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting enzyme 2(ACE2)/angiotensin-(1-...

journal_title：Atherosclerosis

authors： Peltonen T,Näpänkangas J,Ohtonen P,Aro J,Peltonen J,Soini Y,Juvonen T,Satta J,Ruskoaho H,Taskinen P

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To examine the association between cardiovascular reactivity to a set of psychological stressors and carotid artery intima-media thickness, a marker of subclinical cardiovascular disease in healthy adolescents. METHODS:Participants were 25 boys and 23 girls age 14.2 ± 0.9 years who were measured for heart ra...

journal_title：Atherosclerosis

authors： Roemmich JN,Feda DM,Seelbinder AM,Lambiase MJ,Kala GK,Dorn J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during inflammation and oxidative stress. OBJECTIVES:The goal of ...

journal_title：Atherosclerosis

authors： Srivastava S,Sithu SD,Vladykovskaya E,Haberzettl P,Hoetker DJ,Siddiqui MA,Conklin DJ,D'Souza SE,Bhatnagar A

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Early arterial wall changes are already present in the apparently healthy, middle-aged population and continuously progress with age. The aim of our study was to investigate whether 30 days low-dose fluvastatin treatment could improve and reverse these arterial changes that are primarily associated with agein...

journal_title：Atherosclerosis

authors： Lunder M,Janić M,Habjan S,Sabovič M

更新日期：2011-04-01 00:00:00

abstract：:Ezetimibe (Zetia(®), Ezetrol(®), Merck, Whitehouse Station, NJ) is a potent inhibitor of sterol absorption, which selectively blocks the uptake of biliary and dietary cholesterol in the small intestine. Clinical trials have demonstrated the beneficial effects of ezetimibe on the reduction of atherogenic lipoproteins a...

journal_title：Atherosclerosis

authors： Davis HR Jr,Lowe RS,Neff DR

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Monocyte recruitment into the vessel wall is a crucial initial step in vascular repair, arteriogenesis and atherogenesis. Two distinct human monocyte subpopulations can be classified according to their CD14/16 surface expression, namely CD14++CD16-monocytes (CD16-mo) and CD14+CD16+ monocytes (CD16+mo). We in...

journal_title：Atherosclerosis

authors： Czepluch FS,Olieslagers S,van Hulten R,Vöö SA,Waltenberger J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Unstable carotid plaques are associated with an increased incidence of embolic complications after carotid artery stenting (CAS) or carotid endarterectomy (CEA). The aim of this study was to elucidate the relationship between the tissue components of carotid plaques and the incidence of new ipsilateral silen...

journal_title：Atherosclerosis

authors： Yamada K,Yoshimura S,Kawasaki M,Enomoto Y,Asano T,Hara A,Minatoguchi S,Iwama T

更新日期：2011-04-01 00:00:00

abstract：:This review evaluates novel beneficial effects of circulating endothelial progenitor cells (EPCs) as shown by several preclinical studies and clinical trials carried out to test the safety and feasibility of using EPCs. There are 31 registered clinical trials (and many others still ongoing) and 19 published studies. E...

journal_title：Atherosclerosis

authors： Napoli C,Hayashi T,Cacciatore F,Casamassimi A,Casini C,Al-Omran M,Ignarro LJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:We examined socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK for adults with moderate or high risk of coronary heart disease. METHODS:3631 participants in the Whitehall II cohort study (mean age 62.7 years, 91% white) were informed of their risk...

journal_title：Atherosclerosis

authors： Forde I,Chandola T,Raine R,Marmot MG,Kivimaki M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Lipid rafts are cholesterol-enriched microdomains on cell membranes. We hypothesized that these microdomains could involve modified low-density lipoprotein (LDL) uptake. METHODS AND RESULTS:Co-localizations of cholesterol-enriched microdomains and CD204 during the uptake of acetyl LDL (AcLDL) and oxidized LD...

journal_title：Atherosclerosis

authors： Kiyanagi T,Iwabuchi K,Shimada K,Hirose K,Miyazaki T,Sumiyoshi K,Iwahara C,Nakayama H,Masuda H,Mokuno H,Sato S,Daida H

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of pioglitazone on endothelial and adipose tissue dysfunction in newly detected IGT patients with CAD. METHODS AND DESIGN:Participants (n=25) were randomized to treatment with either placebo or pioglitazone (30 mg/day) for 12 weeks. Before and after treatment we evaluated endothelia...

journal_title：Atherosclerosis

authors： Rizza S,Cardellini M,Porzio O,Pecchioli C,Savo A,Cardolini I,Senese N,Lauro D,Sbraccia P,Lauro R,Federici M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:25-Hydroxycholesterol (25HC) and its sulfated metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), regulate certain aspects of lipid metabolism in opposite ways. Hence, the enzyme for the biosynthesis of 25HC3S, oxysterol sulfotransferase (SULT2B1b), may play a crucial role in regulating lipid metabolism. We...

journal_title：Atherosclerosis

authors： Bai Q,Xu L,Kakiyama G,Runge-Morris MA,Hylemon PB,Yin L,Pandak WM,Ren S

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

journal_title：Atherosclerosis

authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

更新日期：2011-02-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) and atherosclerosis are common causes of mortality and morbidity in an aging population. Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis. Angpts can also influence in...

journal_title：Atherosclerosis

authors： Trollope AF,Golledge J

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Proprotein convertase subtilisin-kexin type 9 (PCSK9) promotes low density lipoprotein (LDL) receptor degradation, thereby providing a key pathway for LDL metabolism. PCSK9 mRNA expression may be upregulated by insulin in murine models. Here we examined effects of exogenous hyperinsulinemia on plasma PCSK9 leve...

journal_title：Atherosclerosis

authors： Kappelle PJ,Lambert G,Dullaart RP

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:To evaluate the impact of familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) on arterial properties and the effects of statins. METHODS:We meta-analyzed 51 studies providing data for 4,057 FH patients and 732 FCH patients with random-effects models, meta-regression analysis and pu...

journal_title：Atherosclerosis

authors： Masoura C,Pitsavos C,Aznaouridis K,Skoumas I,Vlachopoulos C,Stefanadis C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:α-Linolenic acid (ALA), the vegetable n-3 fatty acid, appears to have antiatherosclerotic properties akin to those of marine n-3 fatty acids. A prior study in a US population with low fish intake showed an inverse association between ALA intake and carotid plaque. We examined the association between the ALA s...

journal_title：Atherosclerosis

authors： Sala-Vila A,Cofán M,Núñez I,Gilabert R,Junyent M,Ros E

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Fenofibrate, a PPAR-α agonist and rosiglitazone, a PPAR-γ agonist, reduce triglycerides and fatty acids in humans and in animal disease models. The efficacy of PPAR-α agonists in mouse model of human atherosclerosis disease has shown mixed results, and efficacy of PPAR-γ and liver X receptor (LXR) agonists h...

journal_title：Atherosclerosis

authors： Srivastava RA

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...

journal_title：Atherosclerosis

authors： Khang YH,Cho SI,Kim HR

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Increasing age and cholesterol levels, male gender, and family history of early coronary heart disease (CHD) are associated with early onset of CHD in familial hypercholesterolemia (FH). OBJECTIVE:Assess subclinical atherosclerosis by computed tomography coronary angiography (CTCA) and its association with ...

journal_title：Atherosclerosis

authors： Miname MH,Ribeiro MS 2nd,Parga Filho J,Avila LF,Bortolotto LA,Martinez LR,Rochitte CE,Santos RD

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Currently no data exists regarding the outcomes after the novel endothelial progenitor cell capturing stent (EPCcS) placement in bifurcation lesions using a provisional T-stenting. This study evaluates the 1-year clinical outcome in patients treated with the EPCcS for a bifurcation lesion using a provisional ...

journal_title：Atherosclerosis

authors： Beijk MA,Klomp M,Koch KT,Henriques JP,Vis MM,Baan J Jr,Tijssen JG,Piek JJ,de Winter RJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Diabetic patients are characterised by poorer prognosis and more cardiovascular complications compared with non-diabetic patients, which may be due to metabolic abnormalities and atherosclerotic plaque characteristics. METHODS:Patients with unstable angina pectoris were enrolled in the study and divided int...

journal_title：Atherosclerosis

authors： Feng T,Yundai C,Lian C,Zhijun S,Changfu L,Jun G,Hongbin L

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis. Its expression is increased during inflammation and by inflammatory cytokines. Sulforaphane (SFN) is a natura...

journal_title：Atherosclerosis

authors： Kivelä AM,Mäkinen PI,Jyrkkänen HK,Mella-Aho E,Xia Y,Kansanen E,Leinonen H,Verma IM,Ylä-Herttuala S,Levonen AL

更新日期：2010-11-01 00:00:00

abstract：UNLABELLED:Transglutaminases play an important role in vascular remodeling, calcification, cell adhesion and endothelial barrier function. In this study we investigate the influence of combined inhibition of both tissue-type transglutaminase (TG2) and the plasma transglutaminase FXIIIA on early lesion development. MET...

journal_title：Atherosclerosis

authors： Matlung HL,VanBavel E,van den Akker J,de Vries CJ,Bakker EN

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Increased lipid accumulation in cells and tissues is a key phenomenon in the development of obesity, insulin resistance, and atherosclerosis. In the regulation of lipid content of cells and tissues the SREBPs play a dominant role as transcription factors. METHODS:Since growth hormone (GH) affects lipid metab...

journal_title：Atherosclerosis

authors： Kotzka J,Knebel B,Avci H,Jacob S,Nitzgen U,Jockenhovel F,Heeren J,Haas J,Muller-Wieland D

更新日期：2010-11-01 00:00:00

abstract：:Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived me...

journal_title：Atherosclerosis

authors： Fei J,Cook C,Blough E,Santanam N

更新日期：2010-10-01 00:00:00

abstract：:The basic principle for professional conduct of science in all countries and all disciplines is honesty towards oneself and towards others. Therefore it is utmost important that the scientific community prevents scientific misconduct by fostering research integrity. This commentary reports on the experience of a Germa...

journal_title：Atherosclerosis

authors： Beisiegel U

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of atherosclerosis. However, the relationship between blood levels of MMPs and the extent of carotid atherosclerosis remains uncertain. We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-m...

journal_title：Atherosclerosis

authors： Lien LM,Hsieh YC,Bai CH,Chen WH,Chiu HC,Hsieh FI,Shyu KG,Chiou HY,Hsu CY

更新日期：2010-10-01 00:00:00